The science behind NOVO


NOVO is a new and scientific approach to personalised patient nutrition. The NOVO programme is a well-researched and highly effective route to weight loss, increased energy an general well-being. The programme is based on principles within immunology and human metabolism. The rationale is that partially digested food components provoke an immune response.

Dr Sarah Brewer MA MB Bchir graduated from Cambridge University as a doctor in 1983. She was a full-time GP for five years and now works in nutritional medicine. She writes widely on all aspects of health, including integrative medicine and the sensible use of supplements.  She has written over 40 popular self-help books and appears regularly on TV and radio. Sarah is currently completing a Masters Degree in Nutritional Medicine at the University of Surrey, Guildford. Sarah was voted Health Journalist of the Year 2002. Sarah is Immogenics’ Medical Adviser.

She says of the NOVO programme,

“NOVO is an exciting new test for food intolerance. It interprets real-time reactions from over 4 million leucocytes as they initiate all their immune responses, rather than measuring just one of the outcomes of that response, such as serum levels of anti-food IgG antibodies. The NOVO programme therefore stands out as a truly unique approach to weight and health management.”


NOVO Physicians and Nutritionists' briefing paper - Only suitable for fast connections (1.2MB)


References supporting the science behind the NOVO programme are available using the links below:

The case for an immunologic cause of obesity

Regulation of fatty acid oxidation in skeletal muscle

Inflammatory status and insulin resistance


Insulin signal transduction and glucose transport in human adipocytes: effects of obesity and low calorie diet

A rational approach to pathogenesis and treatment of type 2 diabetes mellitus, insulin resistance, inflammation, and atherosclerosis


Cachectin/tumor necrosis factor decreases human adipose tissue lipoprotein lipase mRNA levels, synthesis, and activity

Lipoprotein lipase activity in skeletal muscle is related to insulin sensitivity

Relationship between insulin-mediated glucose disposal and regulation of plasma and adipose tissue lipoprotein lipase 

Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?

Modulation of epithelial permeability by extracellular macromolecules

CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia


Integrative immunophysiology in the intestinal mucosa


Immunophysiology of the gut: a research frontier for integrative studies of the common mucosal immune system

Review article: mechanisms of initiation and perpetuation of gut inflammation by stress

Cell adhesion and migration. I. Neutrophil adhesive interactions with intestinal epithelium.


Intestinal epithelial function: the case for immunophysiological regulation. Implications for disease (2)


Milk proteins, cytokines and intestinal epithelial functions in children


Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease


The sequential release of granule constitutents from human neutrophils

Soluble and insoluble immune complexes activate human neutrophil NADPH oxidase by distinct Fc gamma receptor-specific mechanisms

Molecular events in the activation of human neutrophils for microbial killing

Chemoattractant receptors on phagocytic cells

Modulation of human polymorphonuclear leukocyte IgG Fc receptors and Fc receptor-mediated functions by IFN-gamma and glucocorticoids

The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals


Impairment of function in aging neutrophils is associated with apoptosis

Molecular events in the activation of human neutrophils for microbial killing